Published on 2026-09-18 by vasil078
On October 7, 2026, we hosted the Grossman Center Scientific Seminar, Boosting GABAergic inhibition to restore sleep loss in Alzheimer’s disease, featuring speaker Riley Irmen, PhD candidate, from the University of Kentucky Department of Physiology.
Sleep disruption is an early and prominent feature in Alzheimer’s disease and related tauopathies, however, the mechanisms linking the two remain unclear. Tau pathology causes excitatory/inhibitory imbalance, impaired network synchrony, and sleep loss. Together, these findings point to inhibitory dysfunction as a central feature connecting tau pathology with altered neuronal activity and sleep.
Restoring inhibition may normalize and restore cortical hyperexcitability and improve sleep, highlighting excitatory/inhibitory imbalance as a potential therapeutic target in tauopathies.
